Cytoskeleton: mechanical coupling from plasma membrane to nucleus
European Cytoskeletal Forum Meeting 2017 and FEBS Advanced lecture course


Sunday 4.6.2017

Arrival to conference venue during afternoon

16.00-17.00 Coffee

17.00-19.10 Opening words and plenary lectures

17.00-17.15 Opening words by the ECF president Michael Way and on behalf of organizers, Pekka Lappalainen

17.15-17.30 Claudio M. Soares (Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Portugal): Introduction to the main meeting sponsor FEBS

17.30-18.20 Dennis Discher (Molecular and Cell Biophysics Laboratory, University of Pennsylvania, Philadelphia, USA):  Myosin-II, Matrix Stiffness, and the Nucleus: Interplay in Durotaxis, Differentiation, and DNA damage

18.20-19.10 Richard Treisman (The Francis Crick Institute, London, UK): RPEL Proteins in transcription and cytoskeletal regulation

19.30- Dinner


Monday 5.6.2017

9.00-10.30 Session I: Organelle dynamics and cytoskeleton

9.00-9.30 Roberto Dominguez (Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA): BAR domain proteins linking the cytoskeleton, membranes and signaling pathways

9.30-10.00 Julia von Blume (Max Planck Institute of Biochemistry, Martinsried, Germany): F-actin and cofilin dependent secretory cargo sorting at the transGolgi network (TGN)

10.00-10.15 Pirta Hotulainen (Minerva Institute for Medical Research Helsinki, Finland): Tropomyosin Tpm3.1 is required to maintain the structure and function of the axon initial segment

10.15-10.30 Sharissa Latham (Institute for Biophysical Chemistry Hannover Medical School Germany): Cytoplasmic actin foci: a fine balance of actin isoforms regulates the endocytic pathway at the level of the early endosome

10.30-11.00 Coffee break

11.00-12.00 Session I cont.

11.00-11.30 Henry Higgs (Geisel School of Medicine at Dartmouth, Hanover, USA): Dynamic connections between actin and mitochondria through the formin INF2

11.30-11.45 Jasmine Abella (Cellular Signalling and Cytoskeletal Function, The Francis Crick Institute London, UK): The role of Arp2/3 complex isoforms in invadopodia formation

11.45-12.00 Leonardo Almeida-Souza (MRC Laboratory of Molecular Biology Cambridge, UK): FCHSD2 Promotes Actin Polymerization at the Base of Clathrin Coated Pits

12.00-12.10 Camilo Guzman (Åbo Akademi University, Finland): Finnish Advanced Light Microscopy Node of Euro-BioImaging: Open-access to state-of-the-art technologies in biological imaging

12.15-13.30 Lunch

14.00-16.00 Poster session A

16.00-16.30 Coffee

16.30-18.30 Session II: Cytoskeletal forces during development

16.30-17.00 Jennifer Gallop (Gurdon Institute, Cambridge, UK): Actin dynamics is orchestrated by lipid and curvature microenvironment in endocytosis and Lowe syndrome

17.00-17.15 Thomas Iskratsch (Randall Division of Cell and Molecular Biophysics, King's College London, UK): Alteration of cardiomyocyte mechanosensing through hypertrophic signaling

17.15-17.30 Jaakko Lehtimäki (Institute of Biotechnology, University of Helsinki, Finland): UNC-45a promotes synchronized folding and assembly of bipolar myosin II filaments for stress fibers

17.30-17.45 Amelie Juin (Beatson Institute for Cancer Research, UK): Characterization of the role of N-WASP in Pancreatic Ductal Adenocarcinoma progression and dissemination

17.45-18.00 Matthias Krause (Randall Division King's College London, UK): Nance Horan Syndrome-Like 1 (NHSL1) protein is a novel Ena/VASP and Scar/WAVE ligand and negatively regulates cell migration.

18.00-18.30 Ronen Zaidel-Bar (Mechanobiology Institute Singapore, National University of Singapore, Singapore): Regulation of cortical contractility in the C. elegans zygote

19.00- Dinner

21.00- Sauna


Tuesday 6.6.2017

9.00-10.30 Session III: Mechanotransduction

9.00-9.30 Sari Tojkander (Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Finland): Tension from neighboring cells activates a mechanosensitive pathway to inhibit synthesis of stress fiber precursors in confluent epithelial monolayers

9.30-10.00 Margaret Gardel (Department of Physics, James Franck Institute & Institute for Biophysical Dynamics, University of Chicago, USA): Force Transmission in Multicellular Colonies

10.00-10.15 Mark Morgan (Institute of Translational Medicine, University of Liverpool, UK): Sensing tension: Bidirectional feedback mechanisms controlling cancer invasion

10.15-10.25 Pierre-Olivier Strale (Alveole): Light-induced quantitative photopatterning of biomolecules

10.30-11.00 Coffee break

11.00-12.00 Session III cont.

11.00-11.30 Buzz Baum (MRC Laboratory for Molecular Cell Biology, University College London, UK): The evolution and mechanics of cell division

11.30-11.45 Elisa Närvä (Turku Centre for Biotechnology, University of Turku, Finland): Strong contractile actin fence and cornerstone adhesions direct human pluripotent colony morphology

11.45-12.00 Florence Janody (Instituto Gulbenkian de Ciência Portugal): Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells

12.15-13.30 Lunch

14.00-15.30 Session IV: Nuclear connections to the cytoskeleton

14.00-14.30 Megan King (Department of Cell Biology, Yale University, USA): LINCing up adhesions and the nucleus: roles in tissue integrity and differentiation – IUBMB lecture

14.30-14.45 Ilya Nevzorov (Institute of Biotechnology, University of Helsinki, Finland): Phosphoinositide-binding dependent nuclear localization of myosin 1C: Novel view on nuclear import of soluble cargos

14.45-15.00 Teemu Ihalainen (BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, Finland): Mechanical tension regulates C-terminus accessibility of lamin A/C

15.00-15.30 Gregg Gundersen (Department of Pathology & Cell Biology, Columbia University ; New York, USA): LINCing the nucleus to the cytoskeleton for active movement and homeostatic positioning

15.30-16.00 Coffee break

16.00-17.15 Session IV cont.

16.00-16.30 Jan Lammerding (Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, USA): tba

16.30-16.45 Pedro Monteiro (Barts Cancer Institute, Centre for Molecular Oncology Queen Mary, University of London, UK): Centrosome amplification drives nuclear deformability and translocation during 3-D cell migration

16.45-17.00 Daniel Newman (University of Liverpool, UK): Matrix adhesion site maturation drives 3D cancer cell migration through direct force coupling to the nucleus

17.00-17.30 Xuetong Shen (MD Anderson Cancer Center, USA): Exploring the World of Nuclear Actin and Actin Modification

17.45-19.15 Networking/mentoring event organized by the students

19.30- Dinner

21- Sauna


Wednesday 7.6.2017

9.00-10.30 Session V: Cytoskeletal crosstalk

9.00-9.30 Gijsje Koenderink (FOM Institute AMOLF, Amsterdam, the Netherlands): Cell shape and mechanics control by cytoskeletal crosstalk

9.30-10.00 Frank Bradke (German Center for Neurodegenerative Diseases, Bonn, Germany): ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS

10.00-10.15 Steve Winder (University of Sheffield, UK): Regulated nuclear trafficking of β-dystroglycan

10.15-10.45 Coffee break